Business Ethics: A European Review, EarlyView.

Readers of literary narratives undergo an emotional experience by feeling varied emotions in various ways. While going through a narrative, we assume here, a fictive reader may be absorbed because they very often believe they develop a feel what is to be felt from a perspective presented and, similarly they understand what is to be understood in a given situation and character engaged in highly textually interwoven situation. Therefore, certain techniques and devices are employed by the authors of emotional fiction (...) to engage their readers emotionally and to create text- reader empathy. In this paper, an attempt has been made to discover the lexico-grammatical texturing of emotional fiction using the Corpus Stylistics Framework for identifying emotional intensity based on Systemic Functional Linguistics to unveil how this particular texturing causes emotional immersion. Through a lexico-grammatical analysis of the selected passages of ‘The Bride’, it is established that by using particular lexical choices and devices, the author engages the reader emotionally and therefore, enhances readers’ involvement in the text. Hence, it supports our claim that the lexicogrammar of the emotional passages is instrumentally di?erent for projecting emotionally engaged responses. (shrink)

In P v Cheshire West, Lady Hale stated that an act that would deprive an able-bodied or able-minded person of their liberty would do the same to a mentally or physically disabled person. Throughout the judgement, there is no definition of what liberty is, which makes defining an act that would deprive a person of it difficult. Ideas of liberty are described in terms of political liberty within a society, the state of being free from external influence and individual autonomy. (...) This essay explores various philosophical ideas of liberty and what a legitimate constraint of liberty is. It will be argued that defining liberty in terms external influence from other human agents undermines the impact of natural inability on a person’s ability to fulfil their intrinsic desires—a true constraint of liberty is any which prohibits a person from acting in the way they desire. If liberty is not the same for all, it follows that a deprivation of liberty differs between different agents. Although the government must protect personal liberty, it is important to recognise that an act that may deprive an able-bodied or minded person of their liberty, may in fact promote the liberty of a disabled persons. It will be argued that acts that allow a disabled person to act out desires that they ordinarily would not be able to perform, do not deprive them of their liberty. (shrink)

This chapter analyzes the ‘hard sell’ of genetically engineered (GE) mosquitoes with gene drives as the solution to mosquito-borne diseases. A defining characteristic of the aggressive sell of the bio-technology is the ‘biologization’ of the significant prevalence of mosquito-borne diseases in certain socio-economically marginalized regions of the global South. Specifically, hard sell narratives either minimize or ignore the structural, systemic factors that are partially responsible for the public health problem that the GE mosquitoes are intended to bio-solve. The biologization of (...) a public health problem that disproportionately affects low-income, marginalized populations in certain global South regions has epistemic, epidemiological, and gendered ethico-political costs. The primary focus of this chapter is two scientific papers by researchers with ties to Target Malaria, a research organization developing GE mosquitoes with gene drives as the solution to malaria in the global South. In the interest of a contextualized analysis of the hard sell of GE mosquitoes with gene drives in those scientific papers, this chapter examines the normative commitments of Target Malaria’s key backer, the Bill and Melinda Gates Foundation, a powerful private organization that currently dominates the global health governance stage. (shrink)

According to the ideological surround model of research, a more “objective” psychology of religion requires efforts to bring etic social scientific and emic religious perspectives into formal dialog. This study of 245 Iranian university students illustrated how the dialogical validity of widely used etic measures of religion can be assessed by examining an emic religious perspective on psychology. Integrative Self-Knowledge and Self-Control Scales recorded two aspects of the “Perfect Man” as described by the Iranian Muslim philosopher Mortazā Motahharī. Use of (...) these instruments in correlation and multiple regression procedures identified Intrinsic, Extrinsic Personal, Religious Interpretation, Extrovertive Mysticism, Prayer Fulfillment, Universality, Connectedness, and Religiosity Scales as adaptive in their implications for a Muslim psychology of religion. Religious Crisis had maladaptive and Extrinsic Social, Introvertive Mysticism, and Quest Scales had ambiguous implications. These data illustrated how etic forms of understanding can clarify and can be clarified by emic insights. (shrink)

Gendered Morality offers a textual-critical examination of gender in Islamic metaphysics and virtue ethics. Through a close reading of how masculinity and femininity are constructed, the book argues that the historically contingent nature of gender hierarchy, characterized as Islamic and ethical, is at odds with the overarching goal of Islamic ethics as earthly justice. Because the book moves beyond the typical Qur'anic and jurisprudence-based discourses about women's status, it makes a lasting contribution to our understanding of gender in the ethical (...) philosophy of Islam. (shrink)

Background: Physical restraint is among the commonly used methods for ensuring patient safety in intensive care units. However, nurses usually experience ethical dilemmas over using physical restraint because they need to weigh patient autonomy against patient safety. Aim: The aim of this study was to explore factors behind ethical dilemmas for critical care nurses over using physical restraint for patients. Design: This is a qualitative study using conventional content analysis approach, as suggested by Graneheim and Lundman, to analyze the data. (...) Methods: Seventeen critical care nurses were purposefully recruited from the four intensive care units in Tehran, Iran. Data were collected through in-depth semi-structured interviews and were concurrently analyzed through conventional content analysis as suggested by Graneheim and Lundman. Ethical consideration: This study was approved by the Ethics Committee of Iran University of Medical Sciences, Tehran, Iran with the code: IR.IUMS.REC.1397.795. Before interviews, participants were provided with explanations about the aim of the study, the confidentiality of the data, their freedom to participate, and the right to withdraw the study, and their free access to the study findings. Finally, their consents were obtained, and interviews were started. Results: Factors behind ethical dilemmas for critical care nurses over using physical restraint were categorized into three main categories, namely the outcomes of using physical restraint, the outcomes of not using physical restraint, and emotional distress for nurses. The outcomes of using physical restraint were categorized into the three subcategories of ensuring patient safety, physical damage to patients, and mental damage to the patient. The outcomes of not using physical restraint fell into two subcategories, namely the risks associated with not using physical restraint and legal problems for nurses. Finally, the two subcategories of the emotional distress for nurses main category were nurses’ negative feelings about restraint use and uncertainty over the decision on physical restraint use. Conclusion: Decision-making for restraint use is often associated with ethical dilemmas, because nurses need to weight the outcomes of its use against the outcomes of not using it and also consider patient safety and autonomy. Health authorities are recommended to develop clear evidence-based guidelines for restraint use and develop and implement educational and counseling programs for nurses on the principles of ethical nursing practice, patient rights, physical restraint guidelines and protocols, and management of emotional, ethical, and legal problems associated with physical restraint use. (shrink)

For the purposes of conservation or suppression of species, gene drive technology has significant potential. Theoretically speaking, with the release of even relatively few animals with gene drive systems in an ecosystem, beneficial or harmful genes could be introduced into the entire wild-type population of that species. Given the profound impact that gene drives could have on species and ecosystems, their use is a highly contentious issue. Communities and groups have differing beliefs about nature and its conservation or preservation, as (...) well as concerns about the ecological safety of the eradication, replacement or enhancement of particular species of animals by means of genetic engineering. For all those reasons, the rigorous regulation of insects and other animals with gene drive systems is crucial. In this paper, we consider the question of whether the United States Food and Drug Administration is prepared to effectively regulate insects and other animals with gene drives. (shrink)

It is a widespread belief that Husserl’s conception of time obstructs the way to understanding world-time in a heideggerian sense. Unfolding world-time as one of the main topics of the last phases of Husserl’s analyses of time shall refute this criticism. The process of concretization of the transcendental ego also expresses the silent concretization of the world of phenomenology, and these concretizations lead to the topic of world-time. The study assumes that Husserl’s phenomenology undergoes a process of concretization with its (...) peak in the theme of world-time. (shrink)

In this chapter, Zahra Meghani provides a brief overview of the regulatory framework for consumer products in the United States, the European Union and Japan, followed by an extended analysis of their regulation of genetically modified food. The regulatory regimes for GM food of the three regions differ substantially, but they are committed to the same model of scientific risk assessment. That paradigm assumes that risk evaluations are not influenced by any normative concerns. This chapter critiques that conception of (...) risk assessment. It is argued that in the interest of presenting to the public an accurate account of their work, the regulatory entities of the US, the EU, and Japan should acknowledge that their risk assessment of GM food involve normative choices. Moreover, they should create open, transparent, democratic processes to include the public in the deliberations and decision-making about the values that should shape the risk evaluation of GM foods at every stage of the risk assessment process. (shrink)

The primary responsibility of the US Food and Drug Administration is to protect public health by ensuring the safety of the food supply. To that end, it sometimes conducts risk assessments of novel food products, such as genetically modified food. The FDA describes its regulatory review of GM food as a purely scientific activity, untainted by any normative considerations. This paper provides evidence that the regulatory agency is not justified in making that claim. It is argued that the FDA’s policy (...) stance on GM food is shaped by neoliberal considerations. The agency’s review of a genetically engineered animal, the AquAdvantage salmon, is used as a case study to track the influence of neoliberalism on its regulatory review protocol. After that, an epistemic argument justifying public engagement in the risk assessment of new GM food is outlined. It is because risk evaluations involve normative judgments, in a democracy, layperson representatives of informal epistemic communities that could be affected by a new GM food should have the opportunity to decide the ethical, political or other normative questions that arise during the regulatory review of that entity. (shrink)

We present a hierarchical self-organizing map based system for online recognition of human actions. We have made a first evaluation of our system by training it on two different sets of recorded human actions, one set containing manner actions and one set containing result actions, and then tested it by letting a human performer carry out the actions online in real time in front of the system’s 3D-camera. The system successfully recognized more than 94% of the manner actions and most (...) of the result actions carried out by the human performer. (shrink)

Introduction The discussion of “self-knowledge” as a philosophical issue begins with an intuition. This intuition is based on the fact that our knowledge of our mental states or our knowledge in relation to statements like: “I know that I am happy,” is a particular knowledge that is distinct from the rest of our knowledge. It seems that in order to gain knowledge of ourselves, we do not need to go through those processes that we go through in order to gain (...) knowledge about the external world or knowledge of other minds. We feel that we directly know our own mental states. The role of self-knowledge philosophers is to explain this type of particular knowledge. Theories such as the Inner Sense Theory, the Acquaintance Theory, inferentialism, or theories with a rationalist approach are presented in response to this issue. Considering theories such as the Inner Sense Theory and the Acquaintance Theory, we will find that a common aspect of these theories is that self- knowledge has been defined as a product of an internal observation of our mental states. Such an approach is a kind of Empiricism in self-knowledge. The Rationalist approach has been raised against this approach. This approach, by linking self-knowledge with rationality, has opened a new chapter in the discussion of self-knowledge. The foundation of this approach is based on the principle that our situation as a rational agent plays a fundamental role in self-knowledge. Rationalists believed that this ignorance of the fundamental role of rationality in self-knowledge has caused Empiricists to ignore the most important kind of self-knowledge that is associated with rationality. Tyler Burge, Richard Moran, and Matthew Boyle are some of the important philosophers who theorize about this kind of self-knowledge. Goal In this paper, we will first introduce the main components of Rationalist approaches because we want to review the theoretical literature of this approach. Then, we will bring up a summary of the Tyler Burge view, a famous and important philosopher of the rationalist approach. This is an introduction to introduce Moran’s Theory of Transparency which is the focal point of our discussion. We will then refer to one of the most important challenges facing the Transparency Theory and bring up a significant solution that is presented by Matthew Boyle. We will also show that despite the advantages of this solution, there are ambiguities and other challenges. Finally, we will try to set up two proposals as a way to advance Boyle’s solution. Conclusion The perspective of rationalist philosophers about the existence of a kind of self-knowledge in rational creatures seems to be a powerful idea that is difficult to oppose. Tyler Burge presented interesting arguments about this issue. But it is not easy replying to the question of how this kind of self-knowledge occurs. The theory of Transparency and Reflectivism were proposed to respond to this question. Although they have been considered as efficient theories; however, the mentioned problem still remains ambiguous and complex. Transparency denied the introspective self-knowledge, but couldn’t explain how transparent self-knowledge occurs and therefore, it does not provide a complete explanation for self-knowledge. Some vagueness and some important challenges still continue to exist in this theory. Finally, we propose two proposals as a complement to Boyle’s theory. Maybe they could advance this theory. We suggest that we can use the concept of non-conceptual belief and dispositional belief. These debates have the potential for solving some of the challenges of Transparency and Reflectivism. These are profound topics and need great reflection. We know that our proposals are very elementary and crude ideas. But perhaps they can be a way toward developing the Transparency and Reflectivism theories. (shrink)

In recent years, genetically engineered (GE) mosquitoes have been proposed as a public health measure against the high incidence of mosquito-borne diseases among the poor in regions of the global South. While uncertainties as well as risks for humans and ecosystems are entailed by the open-release of GE mosquitoes, a powerful global health governance non-state organization is funding the development of and advocating the use of those bio-technologies as public health tools. In August 2016, the US Food and Drug Agency (...) (FDA) approved the uncaged field trial of a GE Aedes aegypti mosquito in Key Haven, Florida. The FDA’s decision was based on its assessment of the risks of the proposed experimental public health research project. The FDA is considered a global regulatory standard setter. So, its approval of the uncaged field trial could be used by proponents of GE mosquitoes to urge countries in the global South to permit the use of those bio-technologies. -/- From a public health ethics perspective, this paper evaluates the FDA’s 2016 risk assessment of the proposed uncaged field trial of the GE mosquito to determine whether it qualified as a realistic risk evaluation. -/- The FDA’s risk assessment of the proposed uncaged field trial did not proximate the conditions under which the GE mosquitoes would be used in regions of the global South where there is a high prevalence of mosquito-borne diseases. -/- Given that health and disease have political-economic determinants, whether a risk assessment of a product is realistic or not particularly matters with respect to interventions meant for public health problems that disproportionately impact socio-economically marginalized populations. If ineffective public health interventions are adopted based on risk evaluations that do not closely mirror the conditions under which those products would actually be used, there could be public health and ethical costs for those populations. (shrink)

Neuroarchitecture uses neuroscientific tools to better understand architectural design and its impact on human perception and subjective experience. The form or shape of the built environment is fundamental to architectural design, but not many studies have shown the impact of different forms on the inhabitants’ emotions. This study investigated the neurophysiological correlates of different interior forms on the perceivers’ affective state and the accompanying brain activity. To understand the impact of naturalistic three-dimensional (3D) architectural forms, it is essential to perceive (...) forms from different perspectives. We computed clusters of form features extracted from pictures of residential interiors and constructed exemplary 3D room models based on and representing different formal clusters. To investigate human brain activity during three-dimensional perception of architectural spaces, we used a mobile brain/body imaging (MoBI) approach recording the electroencephalogram (EEG) of participants while they naturally walk through different interior forms in virtual reality (VR). The results revealed a strong impact of curvature geometries on activity in the anterior cingulate cortex (ACC). Theta band activity in ACC correlated with specific feature types (rs (14) = 0.525, p = 0.037) and geometry (rs (14) = - 0.579, p = 0.019), providing evidence for a role of this structure in processing architectural features beyond their emotional impact. The posterior cingulate cortex and the occipital lobe were involved in the perception of different room perspectives during the stroll through the rooms. This study sheds new light on the use of mobile EEG and VR in architectural studies and provides the opportunity to study human brain dynamics in participants that actively explore and realistically experience architectural spaces. (shrink)

The role of experience in the process of behavioral refinement has been undertheorized by philosophers of neuroscience and neuroscientists. By examining sleep studies in behavioral neurobiology, I show that scientists frequently invoke a variety of lived experiences—what I call experientially derived notions—to refine the behavior under investigation. Of note, these behaviors must remain sufficiently fuzzy throughout experimentation to permit refinement. The aim of this article is to recognize that neuroscientists’ use of lived experience necessarily helps refine behaviors and render those (...) behavioral terms relevant to human life. (shrink)

Genetically engineered (GE) insects, such as the GE OX513A Aedes aegypti mosquitoes, have been designed to suppress their wild-type populations so as to reduce the transmission of vector-borne diseases in humans. Apart from the ecological and epidemiological uncertainties associated with this approach, such biotechnological approaches may be used by individual governments or the global community of nations to avoid addressing the underlying structural, systemic causes of those infections... We discuss here key ethical questions raised by the use of GE mosquitoes, (...) with the aim of fostering discussion between the public, researchers, policy makers, healthcare organizations, and regulatory agencies at the local, national, and international levels. We affect that goal by outlining a procedural approach to decision-making about the use of the “biotechnology” that goes beyond “community engagement.” The protocol we advocate for entails informed deliberations and decision-making at the community level. It is designed to ensure that the voices of the marginalized and vulnerable groups that would be disproportionately affected by the decision are heard during the community-wide discussions. Moreover, we make the case that the values embedded in the risk assessment should be identified so that the community can make an informed decision about the use of GE insects. In addition, we advocate for the involvement of a variety of actors whose responsibility would be to ensure that the community has the opportunity to make an informed decision based on deliberations about the use of the “biotechnology.”. (shrink)

Third-order exclusion is a form of epistemic oppression in which the epistemic lifeway of a dominant group disrupts the epistemic agency of members of marginalized groups. In this paper we apply situated perspectives in order to argue that philosophy as a discipline imposes third-order exclusions on members of marginalized groups who are interested in participating in philosophy. We examine a number of specific aspects of the epistemic lifeway embodied by academic philosophy and show how this produces inaccessibility to the discipline. (...) In addition to critiquing the discipline and its methods we also use this discussion to elaborate on third-order exclusion itself. We conclude by proposing an intersectional pedagogy as a step toward creating a more accessible discipline. (shrink)

A mechanistic explanation is a desired outcome in many studies of perception. Such explanations require discovering the processes that contribute to the realization of a perceptual phenomenon at different levels of information processing. The present analysis aims at investigating the obstacles to develop such mechanistic explanations and their potential solutions in the context of psychopathology. Geometric-Optical Illusions (GOIs) are among perceptual phenomena that have been studied to understand psychopathology in various clinical populations. In the present analysis, the GOIs will be (...) discussed as a methodological tool in the investigation of the mechanistic approach to understanding perception in such populations. I will argue that the fact that most such studies are mainly focused on the investigation of susceptibility to GOIs can only lead to classifying such phenomena or to reporting some correlations between different aspects of such phenomena with certain brain activities, without formulating a mechanistic explanation. The investigation of the variables that mediate perceptual phenomena at earlier stages of information processing is required for the formulation of such explanations. Thus, the objective of the present analysis is twofold: 1) showing how ignoring such variables have prevented the formulation of mechanistic explanations of responses to GOIs in clinical populations, such as schizophrenia and autism, 2) analyzing the methodological aspects of an effective approach in which a top-down guidance based on phenomenological insights (the first-person data) along with the insights provided by the existing theories help overcome obstacles in developing mechanistic explanations of GOIs. (shrink)

This article contends that the environmental release of genetically engineered (GE) animals with heritable traits that are patented will present a challenge to the efforts of nations and indigenous peoples to engage in self‐determination. The environmental release of such animals has been proposed on the grounds that they could function as public health tools or as solutions to the problem of agricultural insect pests. This article brings into focus two political‐economic‐legal problems that would arise with the environmental release of such (...) organisms. To address those challenges, it is proposed that nations considering the environmental release of GE animals must take into account the underlying circumstances and policy failures that motivate arguments for the use of the modified animals. Moreover, countries must recognize that the UN International Covenant on Civil and Political Rights and the UN International Covenant on Economic, Social and Cultural Rights place on them an obligation to ensure that GE animals with patented heritable traits are not released without the substantive consent of the nations or indigenous peoples that could be affected. (shrink)

RésuméMullā Ṣadrā explique la connaissance de soi avec la notion de connaissance par la présence, qui fait référence à la présence immédiate du connu avant le connaissant. L'une des composantes énigmatiques de cette connaissance est que le connaissant et le connu sont l'un avec l'autre dans une relation d'unité. Nous pouvons découvrir la motivation de Ṣadrā à évoquer cette idée énigmatique en réfléchissant au point de vue de Sydney Shoemaker sur la connaissance de soi. Nous montrerons que la motivation de (...) Ṣadrā était sa prise de conscience du concept important d'auto-cécité, une notion introduite dans la philosophie contemporaine par Shoemaker. (shrink)

ABSTRACTIn 1960, Eugene P. Wigner shared his observation of the unreasonable effectiveness of mathematics in formulating regularities in nature. Later, Jean Piaget recognized the functioning of the...

Digital piracy is costly to creative economies across the world. Studies indicate that anti-piracy messages can cause people to pirate more rather than less, suggesting the presence of psychological reactance. A gender gap in piracy behavior and attitudes towards piracy has been reported in the literature. By contrast, gender differences in message reactance and the moderating impact of attitudes have not been explored. This paper uses evolutionary psychology as a theoretical framework to examine whether messages based on real-world anti-piracy campaigns (...) cause reactance and whether this effect is explained by gender and pre-existing attitudes. An experiment compares one prosocial and two threatening messages against a control group to analyze changes in piracy intention from past behavior for digital TV/film. Results indicate that the prosocial message has no significant effect, whereas the threatening messages have significantly opposing effects on men and women. One threatening message influences women to reduce their piracy intentions by over 50% and men to increase it by 18%. We find that gender effects are moderated by pre-existing attitudes, as men and women who report the most favorable attitudes towards piracy tend to demonstrate the most polarized changes in piracy intentions. The practical implications of the results are that men and women process threatening messages differently, therefore behavioral change messages should be carefully targeted to each gender. Explicitly, threatening messages may be effective on women, but may have the reverse effect on men with strong favorable attitudes towards the target behavior. (shrink)

In recent years, the flow of undocumented labor from the global South to richer nations has increased considerably. Many undocumented women workers find employment as caregivers for the dependent elderly, whose numbers are burgeoning in affluent countries. Here we present a profile of undocumented non-citizen caregivers in the United States and delineate some of the key injustices they suffer. After identifying the causal factors responsible for the flow of undocumented labor from the global South to richer nations like the United (...) States, we discuss the criteria that a theory of transnational justice must meet if it is to address the problem of justice for this population. We argue that Iris Young's "social connection" model of responsibility is a promising approach for helping to correct the injustices suffered by undocumented, non-citizen caregivers. (shrink)

This paper argues that regulatory agencies have a responsibility to further the public interest when they determine the conditions under which new technological products may be commercialized. As a case study, this paper analyzes the US 9th Circuit Court’s ruling on the efforts of the US Environmental Protection Agency to regulate an herbicide meant for use with seed that are genetically modified to be tolerant of the chemical. Using that case, it is argued that when regulatory agencies evaluate new technological (...) products, they have an obligation to draw on data, analyses, and evaluations from a variety of credible epistemic sources, and not rely solely or even primarily on the technology developer. Otherwise, they create conditions for their own domination and that of the polity by the technology developer. Moreover, in the interest of advancing the public interest, regulatory agencies must evaluate new technologies in a substantively and procedurally unbiased manner. (shrink)

The process of risk assessment of biotechnologies, such as genetically modified organisms (GMOs), has normative dimensions. However, the US’ Food and Drug Administration (FDA) seems committed to the idea that such evaluations are objective. This essay makes the case that the agency’s regulatory approach should be changed such that the public is involved in deciding any ethical or social questions that might arise during risk assessment of GMOs. It is argued that, in the US, neither aggregative nor deliberative (representative) democracy (...) ought to be used to make such determinations. Instead, participatory (deliberative) democracy should be the means by which members of the polity decide which normative concerns ought to underlie FDA’s assessment of GMOs. This paper uses a hypothetical case involving a new GM seed to make that argument. (shrink)

Is the practice of UK patients traveling to India as medical tourists morally justified? This article addresses that question by examining three ethically relevant issues. First, the key factor motivating citizens of the United Kingdom to seek medical treatment in India is identified and analyzed. Second, the life prospects of the majority of the citizens of the two nations are compared to determine whether the United Kingdom is morally warranted in relying on India to meet the medical needs of its (...) citizens. Third, as neoliberal reforms are justified on the grounds that they will help the indigent populations affected by them, the impact of medical tourism-a neoliberal initiative-on India's socially and economically marginalized groups is scrutinized. © 2013, Baywood Publishing Co., Inc. (shrink)

Brain arteriovenous malformations (bAVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracranial bleeding. The mechanism of bAVM formation is poorly understood. Nevertheless, animal studies revealed that gene mutation in endothelial cells (ECs) and angiogenic stimulation are necessary for bAVM initiation. Evidence collected through analyzing bAVM specimens of human and mouse models indicate that cells other than ECs also are involved in bAVM pathogenesis. Both human and mouse bAVMs vessels showed lower mural cell-coverage, suggesting a role of pericytes (...) and vascular smooth muscle cells (vSMCs) in bAVM pathogenesis. Perivascular astrocytes also are important in maintaining cerebral vascular function and take part in bAVM development. Furthermore, higher inflammatory cytokines in bAVM tissue and blood demonstrate the contribution of inflammatory cells in bAVM progression, and rupture. The goal of this paper is to provide our current understanding of the roles of different cellular loci in bAVM pathogenesis. (shrink)

Computational modeling plays an important role in prediction and optimization of real systems and processes. Models usually have some parameters which should be set up to the proper value. Therefore, parameter estimation is known as an important part of the modeling and system identification. It usually refers to the process of using sampled data to estimate the optimum values of parameters. The accuracy of model can be increased by adjusting its parameters to the optimum value which need a richer dataset. (...) One simple solution for having a richer dataset is increasing the amount of data, but that can be costly and time consuming. When using data from animals or people, it is especially important to have a proper plan. There are several available methods for parameter estimation in dynamical systems; however there are some basic differences in chaotic systems due to their sensitivity to initial condition. Accordingly, in this paper, a new cost function which is proper for chaotic systems is applied to the chaotic one-dimensional map. Then the efficiency of a newly introduced intelligent method experimental design in extracting proper data is investigated. The results show the success of the proposed method. (shrink)

Recently, in increasing numbers, citizens of wealthy nations are heading to poorer countries for medical care. They are traveling to the global South as medical tourists because in their home nations either they cannot get timely medical care or they cannot afford needed treatments. This essay offers a robust, particularist ethical assessment of the practice of citizens of richer nations traveling to poorer countries for healthcare.

There is a “revolving door” between federal agencies and the industries regulated by them. Often, at the end of their industry tenure, key industry personnel seek employment in government regulatory entities and vice versa. The flow of workers between the two sectors could bring about good. Industry veterans might have specialized knowledge that could be useful to regulatory bodies and former government employees could help businesses become and remain compliant with regulations. But the “revolving door” also poses at least three (...) ethical and policy challenges that have to do with public trust and fair representation. First, the presence of former key industry personnel on review boards could adversely impact the public’s confidence in regulatory decisions about new technology products, including agrifood biotechnologies. Second, the ‘‘revolving door’’ may result in policy decisions about technologies that are biased in favor of industry interests. And third, the ‘‘revolving door’’ virtually guarantees industry a voice in the policy-making process, even though other stakeholders have no assurance that their concerns will be addressed by regulatory agencies. We believe these three problems indicate a failure of regulatory review for new technologies. The review process lacks credibility because, at the very least, it is procedurally biased in favor of industry interests. We argue that prohibiting the flow of personnel between regulatory agencies and industry would not be a satisfactory solution to the three problems of public trust and just representation. To address them, regulatory entities must reject the traditional notion of objectivity. Instead they should adopt the conception of objectivity developed by Sandra Harding and re-configure their regulatory review on the basis of it. That will ensure that a heterogeneous group of stakeholders is at the decision-making table. The fair representation of interests of different constituencies in the review process could do much to inspire warranted public confidence in regulatory protocols and decisions. (shrink)

The aim of this paper is to make possible dialogue between those who claim that technologies are coded with social, political, or ethical values and those who argue that they are value-neutral. To demonstrate the relevance of this bridge-building project, the controversy regarding agrifood biotechnology will be used as a case study. Drawing on work by L. H. Nelson about the nature of human knowledge-building enterprises and E. F. Kittay’s account of the relationally-constituted self, the argument will be made that (...) all technologies embody the values of the communities that created them. (shrink)

Topology has been characterized as an unsuitable mathematical framework for the investigation of geometric-perceptual phenomena. This has been attributed to the highly abstract nature of topology leading to failures in tasks such as making distinctions between geometrical figures (e.g., a cube versus a sphere) in which the human perceptual system succeeds easily. An alternative thesis is proposed on both philosophical and empirical grounds. The present analysis applies the Müller-Lyer (ML) illusion as a method of investigation to examine the suitability of (...) topology in raising questions about geometric-perceptual phenomena and formulating potential answers to these questions. Not only will it be concluded that topology is a suitable mathematical framework in which one can formulate relevant questions and potential answers with respect to perceptual phenomena such as the ML illusion, it will also be discussed that topology will not be replaced by other means of spatial representation consistent with the findings that indicate its contributions to our daily spatial behavior along with other means such as Euclidean geometry. In addition, the analysis will be discussed with respect to two relevant themes: 1) the implications of the proposed view in relation to Husserl’s phenomenology and 2) the effect of developmental stages and education that may change the involvement of topology in such perceptual responses over time. (shrink)

Genetically engineered animals that are meant for release in the wild could significantly impact ecosystems given the interwoven or entangled existence of species. Therefore, among other things, it is all too important that regulatory agencies conduct entity appropriate, rigorous risk assessments that can be used for informed decision-making at the local, national and global levels about the release of those animals in the wild. In the United States, certain GE animals that are intended for release in the wild may be (...) regulated as new animal drugs by the Food and Drug Administration. This paper argues that the decision to treat them as new animal drugs is attributable to the influence of neoliberalism on the US biotechnology regulatory policy framework. The case is made that there should be public democratic deliberations and decision-making about the values and concerns that should guide the nation’s biotechnology regulatory policy paradigm, including the risk assessment process for GE animals meant for release in the wild. -/- . (shrink)

Zahra Thani & Derek Anderson ABSTRACT: Third-order exclusion is a form of epistemic oppression in which the epistemic lifeway of a dominant group disrupts the epistemic agency of members of marginalized groups. In this paper we apply situated perspectives in order to argue that philosophy as a discipline imposes third-order exclusions on members of marginalized ….

Personal narratives on changing needs of life, relationship of man with himself, understanding and doubts.